BACKGROUND & OBJECTIVE: Mesenchymal TUMOR of the GASTROINTESTINAL tract comprises a diverse group of neoplasms which occurs in adults. With recognition of immunohistochemical profile in recent years, GASTROINTESTINAL STROMAL TUMOR (GIST) has been grouped separately from other sarcomas. No therapeutic modality except. Surgey has ever demonstrated definitive evidence of clinical benefit in GIST. These TUMORs occur most commonly in the stomach, followed by small intestine, and are rare in the colon and rectum and extremely rare in the esophagus. GIST also arises rarely in the omentum, mesentery and peritoneum.CASE: A 69-year-old male was admitted to surgical ward with clinical and CT scan findings of large, movable abdominal mass behind the stomach with probable origin from the pancreas. Explorative laparatomy revealed an 18 x 16 cm mass in lesser omentum. Pathological and immunohistochemical techniques revealed malignant GIST.CONCLUSION: GASTROINTESTINAL STROMAL TUMOR should be considered in the differential diagnosis of the abdominal mass.

Calcifying fibrous TUMOR (CFT) is a rare mesenchymal TUMOR, affecting children and young adults with a predilection for the soft tissue and the abdominal cavity. CFT of the tubular GASTROINTESTINAL tract is very rare with less than 20 cases of gastric CFTs reported in English literature. This benign hypocellular fibrosclerotic calcifying lesion can resemble other spindle cell TUMORs particularly sclerosing GASTROINTESTINAL STROMAL TUMOR of the stomach. Differentiating between these lesions is particularly important for prognostic and therapeutic purposes. Herein a case of gastric calcifying fibrous TUMOR incidentally detected during bariatric surgery in a 27-year-old woman is described, with a discussion on its clinicopathological features and differential diagnoses.

GASTROINTESTINAL STROMAL TUMORs are mesenchymal neoplasms of the GASTROINTESTINAL tract that originate from all areas of the GASTROINTESTINAL tract. Metastases to the liver, peritoneum, bones, lungs and soft tissues have been reported. We present the case of a 47- year-old woman with rectal GASTROINTESTINAL STROMAL TUMOR that underwent wide local excision. She was treated with imatinib for a few months after surgery. After eight months, she was admitted to the emergency service with complaints of epigastric pain, nausea, vomiting, and anorexia. Imaging studies showed the presence of a pancreatic head TUMOR and three hepatic masses. The patient underwent exploratory laparatomy.Excisional biopsy of one hepatic mass and core needle biopsy of the pancreatic head mass revealed metastases to the liver and pancreas. During the hospital course the patient' s condition deteriorated and she subsequently expired.

Introduction: GASTROINTESTINAL STROMAL TUMORs (GIST) represent less than 1% of all GASTROINTESTINAL TUMORs. The GIST diagnosis in a patient with a newly discovered myasthenia gravis (MG) raises the problem of evolution and treatment.Case Presentation: We present the case of a 58-year-old patient, who has been diagnosed withMGon December 2015 at emergency clinical county hospital Brasov, Romania. After further investigations, a localized gastric GIST was discovered. The treatment was surgical (January 2016) and the one-year evolution after the surgery was without relapse. Genetic mutations in the KIT and PDGFR genes were investigated.Conclusions: GIST may be accidentally discovered in asymptomatic patients. Genetic mutation examinations are needed in order to provide evidence. MG in association with GIST is rare and raises problems of diagnosis and treatment.

This report describes the histological and immunohistochemical features of a small intestinal TUMOR that resembled a human GASTROINTESTINAL STROMAL TUMOR (GISTs) in a seven-year-old male cross-breed dog. This was unique because of the expression of desmin by the TUMOR. Grossly, the white-gray TUMOR measured 8.0´4.0´6.5 cm and was 760 gram in weight. It was cystic and enveloped the jejunum. 100 and C-KIT and negative for CD34 on immunohistochemistry. The expression of desmin in the cytoplasmof this TUMOR cells is a rare event in these types of TUMORs. Histopathologically, long spindleshaped cells were arranged densely in the interwoven pattern. The TUMOR cells had a low rate of mitosis, were pleomorphic, and were positive for vimentin, a-smooth muscle actin, desmin, S100 and C-KIT and negative for CD34 on immunohistochemistry. The expression of desmin in the cytoplasm of this TUMOR vells is a rare event in these types of TUMORs.

GASTROINTESTINAL STROMAL TUMORs (GIST) are less prevalent mesenchymal TUMORs, accounting for 1% of GASTROINTESTINAL malignancies. Spontaneous hemoperitoneum (SH) following gastric GIST rupture is a rare occurrence. The present study described a case of a 67-year-old female who presented with acute onset abdominal pain. Vital signs at the time of presentation were unstable. Contrast-enhanced computed tomography (CECT) of the abdomen revealed a mixed-density mass lesion with multiple hyperdense areas within. A hemogram indicated a low hemoglobin level. An emergency laparotomy revealed a ruptured pedunculated, friable mass with active bleeding arising from the lesser curvature of the stomach. A wedge resection was carried out to achieve a gross negative margin of the mass. Final pathology confirmed GIST epitheloid type with positive margins (pT3N0M0-pathologically TUMOR size within 10 cm with no nodal or distant metastasis) and positive for CD117, DOG1.Given the TUMOR rupture and positive margins, the patient was started on imatinib mesylate therapy. As demonstrated in this case, GIST rarely ruptures, resulting in hemoperitoneum. The primary treatment approach is surgical exploration and resection.

GASTROINTESTINAL STROMAL TUMORs (GISTs) are rare mesenchymal TUMORs that almost always arise from the GI tract and account for 0. 1-3% of GI TUMORs. During pregnancy, GIST is highly unusual given the predilection of this TUMOR to appear in the fifth to seventh decade of life. The finding of GISTs outside the GI tract is also rare as the cell of origin of these TUMORs is believed to be the interstitial cell of Cajal, found only in the GI tract. Extra intestinal GISTs have been reported with a few cases arising from the uterus or metastatic to the ovary; however; an asymptomatic uterine GIST occurring at pregnancy as an incidental finding during cesarean section has not been reported so far. We present a 32-year-old lady who underwent an emergency caesarean section and was found to have a GIST of the uterus. The TUMOR was excised in toto and she started imatinib therapy postoperatively. At the end of three years of close follow-up, she has done well with no evidence of recurrence.

GASTROINTESTINAL STROMAL TUMORs (GISTs) are the most common GASTROINTESTINAL mesenchymal TUMORs and in 80% of the cases are associated with KIT activating mutations. The incidence of GISTs is generally 10-20 cases per million population, which turn out to be malignant in 20-30% of cases. GISTs can be large and present with dysphagia, even though they are usually small and asymptomatic. A 67-year-old woman was referred to the hospital complaining of pain and burning in epigastric area and left flank; the patient had experienced a weight loss within one month before the admission. Primary investigations upon upper endoscopy revealed a submucosal mass in distal part of esophagus, and nodularity and erythema in stomach. But through more examinations by MDCT of Abdomen and Pelvis, a mass measuring 20*33 mm in cardiac and lesser curvature submucosa, without lymphadenopathy was reported, that could suggest GIST. This mass was excised with normal margins via wide local excision, bilayer cardiplasty and funduplication. The patient was hospitalized for 10 days after surgery, and was discharged with good general condition. In follow-up, there wasn’ t any sign of dysphagia and dyspepsia within 24 months. In the patients suffering from GIST, the TUMOR location appears to have the most important role on deciding whether to perform local excision or not. Treatment of GISTs locating near gastroesophageal junction (GE junction) is still challenging. Using an appropriate therapeutic method is crucial in improving the patient’ s quality of life. Therefore, wide local excision followed by bilayer cardiplasty and funduplication, could be considered as the appropriate therapeutic protocol in such same situations due to elimination of post total gastrectomy adverse effects and the TUMOR relapse.

The GASTROINTESTINAL STROMAL TUMOR (GIST) is a rare mesenchymal TUMOR of GASTROINTESTINAL (GI) tract. This TUMOR has tendency to liver metastasis and peritoneal recurrence, however; the primarily lymph node involvement or metastasis is rare. Here we reported a 17-years-old girl with multifocal gastric GIST and multiple lymph node involvement at presentation and recurrence in celiac lymph nodes. We also review some case reports on lymph node metastasis in GIST.